https://biosig.lab.uq.edu.au/ 1, 2 mCSM: predicting the effects of mutations in proteins using graph-based signatures (2014)3 CSM-lig: a web server for assessing and comparing protein-small molecule affinities (2016)4 pdCSM-cancer: Using Graph-Based Signatures to Identify Small Molecules with Anticancer Properties (2021)5 CSM-AB: graph-based antibody-antigen binding affinity prediction and docking scoring function. (Bioinformatics 2022)6 http://biosig.unimelb.edu.au/csm_ab/d… 7,8 1 da Silveira, C. H. et al. Protein cutoff scanning: A comparative analysis of cutoff dependent and cutoff free methods for prospecting contacts in proteins. Proteins: Structure, Function, and Bioinformatics 74, 727-743 (2009). 2 Pires, D. E. et al. in BMC genomics. 1-11 (Springer). 3 Pires, D. E., Ascher, D. B. & Blundell, T. L. mCSM: predicting the effects of mutations in proteins using graph-based signatures. Bioinformatics 30, 335-342 (2014). 4 Pires, D. E. & Ascher, D. B. CSM-lig: a web server for assessing and comparing protein–small molecule affinities. Nucleic acids research 44, W557-W561 (2016). 5 Al-Jarf, R., de Sá, A. G., Pires, D. E. & Ascher, D. B. pdCSM-cancer: using graph-based signatures to identify small molecules with anticancer properties. Journal of Chemical Information and Modeling 61, 3314-3322 (2021). 6 Myung, Y., Pires, D. E. & Ascher, D. B. CSM-AB: Graph-based antibody–antigen binding affinity prediction and docking scoring function. Bioinformatics 38, 1141-1143 (2022). 7 Penque, B. A. et al. A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death. Eur J Med Genet 62, 103574 (2019). https://doi.org:10.1016/j.ejmg.2018.11.008 8 Su, L., Wang, X., Wang, J., Luh, F. & Yen, Y. Impact of N221S missense mutation in human ribonucleotide reductase small subunit b on mitochondrial DNA depletion syndrome. Scientific Reports 13, 19899 (2023).
Machine Learning Algorithm CSM (Cutoff Scanning Matrix) and its Applications in Protein Stability Predication, Protein Classification, Drug Discovery, Antibody Design, & Beyond/ Leila Su/ 01262024
